Restriction of immunoglobulin heterogeneity, autoimmunity and serum protein levels in aged people

Clin Exp Immunol. 1976 Nov;26(2):280-5.


Ninety-one sera of persons above 80 years of age were screened for autoantibody activity against lipoproteins (anti-LDL 7, anti-HDL 6 positive), for rheumatoid factor activity (Latex 14, Waaler-Rose 7 positive) and for antinuclear factors (11 positive). Among the sera with autoantibody activity 29 percent showed deviations of the normal kappa/lambda ratio of immunoglobulins, as opposed to 22 percent of the sera without detected autoantibody activity. In 3 percent of the sera an M component was detected. Determination of the alpha1-acid glycoprotein, alpha1-antitrypsin, haptoglobin, haemopexin, complement component C3c and C4, IgG, IgA and IgM levels showed significant increases in alpha-, and beta-globulins as well as in IgG and IgA in sera of the aged persons as compared to a normal population between 20 and 60 years old. No significant difference was noted between the gamma-globulin concentration in sera of aged persons with or without autoantibody activity. The evaluation of the relationship between serum protein levels and alterations of the kappa/lambda ratio indicated that the alpha- and the beta-globulins were significantly raised in sera with altered kappa/lambda ratios, whereas, with the exception of M component containing sera the gamma-globulin levels seemed not significantly affected by changes in this ratio.

MeSH terms

  • Aged
  • Aging*
  • Alpha-Globulins / analysis
  • Antibodies, Antinuclear / analysis
  • Autoantibodies / analysis*
  • Beta-Globulins / analysis
  • Blood Proteins*
  • Humans
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Immunoglobulins / analysis*
  • Lipoproteins, HDL / immunology
  • Lipoproteins, LDL / immunology
  • Lipoproteins, VLDL / immunology
  • Rheumatoid Factor / analysis
  • gamma-Globulins / analysis


  • Alpha-Globulins
  • Antibodies, Antinuclear
  • Autoantibodies
  • Beta-Globulins
  • Blood Proteins
  • Immunoglobulin A
  • Immunoglobulin G
  • Immunoglobulin M
  • Immunoglobulins
  • Lipoproteins, HDL
  • Lipoproteins, LDL
  • Lipoproteins, VLDL
  • gamma-Globulins
  • Rheumatoid Factor