[Meiotic maturation of the ovocyte of Xenopus laevis : a 4-step mechanism]

C R Seances Acad Sci III. 1981 Jan 5;292(1):65-7.
[Article in French]

Abstract

Microinjection of the pure inhibitor (1) of cAMP dependent protein kinases (1.5 muM) into Xenopus oocytes triggered 100% germinal vesicle break down (GVBD), faster than progesterone and slower than the maturation promoting factor (MPF). Cholera toxin does not block (I) induced maturation; however cycloheximide inhibits (I) but not MPF induced GVBD.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cyclic AMP
  • Cycloheximide / pharmacology
  • Female
  • Growth Substances / pharmacology
  • Maturation-Promoting Factor
  • Meiosis* / drug effects
  • Oocytes / cytology*
  • Ovum / cytology*
  • Progesterone / pharmacology
  • Protein Kinase Inhibitors
  • Protein Kinases / metabolism
  • Xenopus laevis

Substances

  • Growth Substances
  • Protein Kinase Inhibitors
  • Progesterone
  • Cycloheximide
  • Cyclic AMP
  • Protein Kinases
  • Maturation-Promoting Factor