Molecular analysis of the unc-54 myosin heavy-chain gene of Caenorhabditis elegans

Nature. 1981 Jun 4;291(5814):386-90. doi: 10.1038/291386a0.


The properties of a small internal deletion mutant, E675, have been exploited in the molecular cloning of the unc-54 gene. This mutation uniquely identifies unc-54 sequences as molecules of altered length in E675 and provides a genetic and physical marker for the active gene, its messenger RNA and its protein product.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Base Sequence
  • Caenorhabditis / genetics*
  • Cloning, Molecular*
  • DNA Restriction Enzymes
  • DNA, Recombinant / metabolism*
  • Genes*
  • Mutation
  • Myosins / genetics*
  • Plasmids
  • Protein Biosynthesis
  • RNA, Messenger / genetics
  • RNA, Messenger / isolation & purification
  • Transcription, Genetic


  • DNA, Recombinant
  • RNA, Messenger
  • DNA Restriction Enzymes
  • Myosins