Primary structure, gene organization and polypeptide expression of poliovirus RNA

Nature. 1981 Jun 18;291(5816):547-53. doi: 10.1038/291547a0.


The primary structure of the poliovirus genome has been determined. The RNA molecule is 7,433 nucleotides long, polyadenylated at the 3' terminus, and covalently linked to a small protein (VPg) at the 5' terminus. An open reading frame of 2,207 consecutive triplets spans over 89% of the nucleotide sequence and codes for the viral polyprotein NCVPOO. Twelve viral polypeptides have been mapped by amino acid sequence analysis and were found to be proteolytic cleavage products of the polyprotein, cleavages occurring predominantly at Gln-Gly pairs.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Genes, Viral*
  • Molecular Weight
  • Nucleic Acid Conformation
  • Peptide Biosynthesis
  • Poliovirus / genetics*
  • Protein Biosynthesis*
  • RNA, Viral / genetics*
  • Ribonuclease T1
  • Viral Proteins / genetics


  • RNA, Viral
  • Viral Proteins
  • Ribonuclease T1

Associated data

  • GENBANK/J02281