Distribution of steroid hormone receptors in human soft tissue sarcomas

Surgery. 1981 Aug;90(2):149-53.


Sixty-six human soft-tissue sarcoma specimens were assayed for incidence and distribution of steroid hormone receptors. Liposarcomas (43%) and leiomyosarcomas (60%) had a high incidence of estrogen receptor. In contrast, sarcomas of fibrous and synovial tissue origin lacked any detectable receptor for estrogen. Malignant fibrous histiocytoma had the highest incidence of glucocorticoid (66%) and androgen (66%) receptors. The incidence of receptors for estrogen and glucocorticoid was higher in female than in male patients (62% and 38%, respectively). Sucrose density gradients demonstrated 8s-type receptors for both estrogen and glucocorticoid. Data from this study suggest that specific high-affinity cytosolic receptors for steroid hormones are present in human soft tissue sarcoma and that their distribution may depend on the histogenetic origin and the sex of patients.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Child
  • Female
  • Histiocytoma, Benign Fibrous / analysis
  • Humans
  • Leiomyosarcoma / analysis
  • Liposarcoma / analysis
  • Male
  • Middle Aged
  • Receptors, Androgen / analysis
  • Receptors, Estrogen / analysis
  • Receptors, Glucocorticoid / analysis
  • Receptors, Steroid / analysis*
  • Sarcoma / analysis*
  • Sex Factors
  • Soft Tissue Neoplasms / analysis*


  • Receptors, Androgen
  • Receptors, Estrogen
  • Receptors, Glucocorticoid
  • Receptors, Steroid