Acute enhancement of spinal cord synaptosomal (Na+ + K+)-ATPase activity in cats following intravenous methylprednisolone

Brain Res. 1981 Aug 31;219(2):464-9. doi: 10.1016/0006-8993(81)90311-5.

Abstract

The acute intravenous administration of high doses of methylprednisolone sodium succinate (15-90 mg/kg) to cats enhanced (Na+ + K+)-ATPase activity as much as 2-fold in synaptosomes prepared from lumbar spinal cord removed following drug administration. The effect was apparent within 5 min and was statistically significant at 1 h following a single injection of methylprednisolone 90 mg/kg. (Na+ + K+)-ATPase activity had returned to control levels by 24 h post-injection. The implication of these findings to the treatment of spinal cord trauma and the reported neurophysiological effects of glucocorticoids are discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cats
  • Dose-Response Relationship, Drug
  • Enzyme Activation / drug effects
  • Female
  • Infusions, Parenteral
  • Male
  • Methylprednisolone / pharmacology*
  • Sodium-Potassium-Exchanging ATPase / metabolism*
  • Spinal Cord / drug effects*
  • Spinal Cord / enzymology
  • Synaptosomes / drug effects*
  • Synaptosomes / enzymology

Substances

  • Sodium-Potassium-Exchanging ATPase
  • Methylprednisolone