Inhibition of lactation and inhibition of prolactin release after mechanical breast stimulation in puerperal women given tamoxifen or placebo

Br J Obstet Gynaecol. 1978 Feb;85(2):134-7. doi: 10.1111/j.1471-0528.1978.tb10467.x.


Tamoxifen was given orally to 60 puerperal women to inhibit lactation. Twenty control puerperal women were given placebo. Fifteen women receiving tamoxifen and 15 women receiving placebo were studied before, during and after the use of a breast pump under basal conditions and after five days of treatment. Tamoxifen was effective in inhibiting lactation; no rebound phenomena were observed. Its administration was free from side effects. This drug was capable of preventing the prolactin release induced by mechanical breast stimulation. Placebo failed to inhibit lactation and had no effect on prolactin release induced by the use of a breast pump.

Publication types

  • Clinical Trial
  • Controlled Clinical Trial

MeSH terms

  • Adult
  • Breast / physiology
  • Depression, Chemical
  • Female
  • Humans
  • Lactation / drug effects*
  • Physical Stimulation
  • Postpartum Period*
  • Pregnancy
  • Prolactin / metabolism*
  • Tamoxifen / pharmacology*


  • Tamoxifen
  • Prolactin