Reciprocal antagonism between ACTH1-24 and beta-endorphin in rats

Neurosci Lett. 1981 Jun 12;24(1):71-4. doi: 10.1016/0304-3940(81)90361-x.

Abstract

ACTH1-24 and beta-endorphin simultaneously injected at 5-10 microgram dose into the lateral ventricle, reciprocally suppress most of their respective behavioural effects (stretching-yawning syndrome, sexual excitement and hyperalgesia for ACTH1-24 and catalepsy and analgesia for beta-endorphin). The results obtained support the hypothesis that ACTH1-24 and beta-endorphin might interact antagonistically at CNS level.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adrenocorticotropic Hormone / analogs & derivatives*
  • Animals
  • Behavior, Animal / drug effects*
  • Cosyntropin / pharmacology*
  • Drug Antagonism
  • Endorphins / pharmacology*
  • Humans
  • Male
  • Penis / drug effects
  • Rats

Substances

  • Endorphins
  • Cosyntropin
  • Adrenocorticotropic Hormone