[Effect of methanedienone (methandrostenolone) on energy processes and carbohydrate metabolism in rat liver cells]

Farmakol Toksikol. Mar-Apr 1981;44(2):213-7.
[Article in Russian]

Abstract

It was found that methandienone administered through a gastric tube in daily doses of 1 mg/kg of body weight for 20 days induces significant changes in carbohydrate metabolism and in energy processes of the rat liver cell. Methandienone itself enhances glycogenolysis and anaerobic glycolysis, reduces cell respiration and does not affect the intensity and effectiveness of oxidative phosphorylation evaluated with succinate as a substrate. It is suggested that reduction of the cell respiration with concurrent enhancement of anaerobic glycolysis by methandienone seems to be the result of cell metabolism transposition on the oxygen-more-independent pathway.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Carbohydrate Metabolism
  • Electron Transport Complex IV / metabolism
  • Energy Metabolism / drug effects*
  • Female
  • Glycolysis / drug effects
  • Liver / metabolism*
  • Liver Glycogen / metabolism
  • Methandrostenolone / pharmacology*
  • Oxidative Phosphorylation / drug effects
  • Phosphorylases / metabolism
  • Rats
  • Succinate Dehydrogenase / metabolism

Substances

  • Liver Glycogen
  • Methandrostenolone
  • Succinate Dehydrogenase
  • Electron Transport Complex IV
  • Phosphorylases