Dilute (d) coat colour mutation of DBA/2J mice is associated with the site of integration of an ecotropic MuLV genome

Nature. 1981 Oct 1;293(5831):370-4. doi: 10.1038/293370a0.


The single endogenous DBA/2J ectropic provirus segregated concordantly with the dilute (d) coat colour mutation on chromosome 9 in 53/53 DBA/2J-derived recombinant inbred mouse strains and all seven inbred and mutant strains tested that carry the d allele. Analysis of DNA from a spontaneous DBA/2J d revertant (d+2J) showed that these mice lack ecotropic-specific MuLV DNA sequences and suggested that the dilute mutation resulted from integration of an ecotropic provirus into the mouse genome.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Base Sequence
  • Cell Transformation, Viral
  • Chromosome Mapping
  • DNA, Viral / genetics
  • Genetic Linkage
  • Leukemia Virus, Murine / genetics*
  • Mice
  • Mice, Inbred DBA / genetics*
  • Mice, Mutant Strains / genetics*
  • Recombination, Genetic


  • DNA, Viral