Abstract
Stimulation of the beta-adrenergic receptor increases the enzymatic methylation of membrane phospholipids. Increased synthesis of phosphatidyl-N-monomethylethanolamine by methyltransferase I increases fluidity and enhances the ability of the beta-adrenergic receptor to couple with adenylate cyclase. The number of beta-adrenergic receptors can be regulated by the rate of synthesis and of degradation of phosphatidylcholine formed by transmethylation.
MeSH terms
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Animals
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Cell Membrane / metabolism
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Erythrocyte Membrane / metabolism
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Isoproterenol / pharmacology
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Lipid Bilayers
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Membrane Fluidity
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Membrane Lipids / physiology*
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Methylation
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Methyltransferases / metabolism*
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Phospholipids / physiology*
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Receptors, Adrenergic / metabolism*
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Receptors, Adrenergic, beta / metabolism*
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Reticulocytes / metabolism
Substances
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Lipid Bilayers
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Membrane Lipids
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Phospholipids
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Receptors, Adrenergic
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Receptors, Adrenergic, beta
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Methyltransferases
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Isoproterenol