Regulation of the beta-adrenergic receptor by methylation of membrane phospholipids

Adv Cyclic Nucleotide Res. 1981;14:83-91.

Abstract

Stimulation of the beta-adrenergic receptor increases the enzymatic methylation of membrane phospholipids. Increased synthesis of phosphatidyl-N-monomethylethanolamine by methyltransferase I increases fluidity and enhances the ability of the beta-adrenergic receptor to couple with adenylate cyclase. The number of beta-adrenergic receptors can be regulated by the rate of synthesis and of degradation of phosphatidylcholine formed by transmethylation.

MeSH terms

  • Animals
  • Cell Membrane / metabolism
  • Erythrocyte Membrane / metabolism
  • Isoproterenol / pharmacology
  • Lipid Bilayers
  • Membrane Fluidity
  • Membrane Lipids / physiology*
  • Methylation
  • Methyltransferases / metabolism*
  • Phospholipids / physiology*
  • Receptors, Adrenergic / metabolism*
  • Receptors, Adrenergic, beta / metabolism*
  • Reticulocytes / metabolism

Substances

  • Lipid Bilayers
  • Membrane Lipids
  • Phospholipids
  • Receptors, Adrenergic
  • Receptors, Adrenergic, beta
  • Methyltransferases
  • Isoproterenol