An autoradiographic study of satellite cell differentiation into regenerating myotubes following transplantation of muscles in young rats

Cell Tissue Res. 1978 Jan 31;186(3):535-40. doi: 10.1007/BF00224941.


Satellite cells were traced autoradiographically during the regeneration of skeletal muscle in young Sprague-Dawley rats. Approximately 31% of the satellite cells in uninjured muscles appeared labelled after three injections of tritiated thymidine; none of the myonuclei were labelled in the same muscles. Four to six days after transplanting the radioactive muscles to non-radioactive littermates, regenerating myotube nuclei in the host appeared labelled. Thus, this study confirms that satellite cells in young rats can differentiate into multinucleated myotubes following muscle injury.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Autoradiography
  • Cell Differentiation
  • Female
  • Male
  • Microscopy, Electron
  • Muscles / physiology
  • Muscles / transplantation*
  • Muscles / ultrastructure
  • Rats
  • Regeneration
  • Time Factors
  • Transplantation, Homologous