Hemopyrrole and kryptopyrrole are absent from the urine of schizophrenics and normal persons

Clin Chem. 1978 Feb;24(2):230-3.

Abstract

We describe a method for detecting hemopyrrole and kryptopyrrole in urine, with a detection limit of 100 mug/liter (1 part in 10(7)). Urine is thoroughly extracted with methylene chloride and the extract is concentrated and examined by gas chromatography and gas chromatography-mass spectrometry. No hemopyrrole or kryptopyrrole could be detected in 52 samples, from 17 controls, 29 schizophrenics, and six persons with acute intermittent porphyria.

MeSH terms

  • Chromatography, Gas
  • Humans
  • Mass Spectrometry
  • Methods
  • Porphyrias / urine
  • Pyrroles / chemical synthesis
  • Pyrroles / urine*
  • Schizophrenia / urine*

Substances

  • Pyrroles
  • hemopyrrole
  • kryptopyrrole