Cannabinoids in glaucoma: a primary screening procedure

J Clin Pharmacol. 1981 Aug-Sep;21(S1):472S-478S. doi: 10.1002/j.1552-4604.1981.tb02627.x.


A procedure was developed for screening of cannabinoids for their ability to reduce intraocular pressure (IOP) using normal rabbits. Eight animals per group were used for statistical significance of data. A negative control group was used for every screen as well as a positive control with 1.5 mg/kg delta 9-THC given intravenously (I.V.). All compounds were tested by I.V. injection and IOP measurements were taken periodically for 5 hours. Data were analyzed by a computer program which takes into account the change in IOP of the control group. Following this procedure we found that delta 8-THC, delta 9-THC, cannabinol, and nabilone were active while cannabidiol was inactive.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Cannabidiol / therapeutic use
  • Cannabinoids / therapeutic use*
  • Cannabinol / therapeutic use
  • Dronabinol / analogs & derivatives
  • Dronabinol / pharmacology
  • Dronabinol / therapeutic use
  • Drug Evaluation, Preclinical
  • Female
  • Glaucoma / drug therapy*
  • Glaucoma / physiopathology
  • Intraocular Pressure / drug effects
  • Male
  • Rabbits


  • Cannabinoids
  • Cannabidiol
  • nabilone
  • Dronabinol
  • Cannabinol