Mast cells and tumor angiogenesis

Int J Cancer. 1976 Nov 15;18(5):703-9. doi: 10.1002/ijc.2910180520.


Tumor angiogenesis factor (TAF) elicits a strong vasoproliferative response when implanted upon the chorioallantoic membrane (CAM) of the chick embryo. This response is first observed stereomicroscopically 2-3 days after implantation. A 40-fold increase in mast cell density is observed within the vicinity of this implant by 24 h. Mast cells that have been isolated from retired breeder Sprague-Dawley rats fail to evoke a vascular reaction when implanted on the CAM. An intermediate role for the mast cell in tumor angiogenesis is suggested.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Angiogenesis Inducing Agents / pharmacology*
  • Animals
  • Blood Vessels / drug effects
  • Cell Count
  • Cell Survival / drug effects
  • Chick Embryo
  • Extraembryonic Membranes / drug effects*
  • Growth Substances / pharmacology*
  • Mast Cells / drug effects*
  • Neoplasms, Experimental / etiology*
  • Rats
  • Sodium Hydroxide / pharmacology
  • Staining and Labeling
  • Time Factors


  • Angiogenesis Inducing Agents
  • Growth Substances
  • Sodium Hydroxide