Multiple arrangements of viral DNA and an activated host oncogene in bursal lymphomas

Nature. 1982 Jan 21;295(5846):209-14. doi: 10.1038/295209a0.


Proviruses of avian leukosis virus (ALV) are located in the vicinity of a putative cellular oncogene (c-myc) in ALV-induced bursal lymphomas. Enhanced expression of c-myc occurs in association with proviruses found in any of three configurations: (I) on the 5' side ('upstream') of c-myc in the same transcriptional orientation; (II) on the 3' side ('downstream') of c-myc in the same orientation; (III) upstream, in the transcriptional orientation opposite to that of c-myc. Thus, activation of adjacent cellular genes by retroviral DNA can involve mechanisms other than provision of a transcriptional promoter.

MeSH terms

  • Animals
  • Avian Leukosis / microbiology*
  • Avian Leukosis Virus / genetics
  • Base Sequence
  • Chickens
  • DNA Restriction Enzymes
  • DNA, Viral / genetics*
  • Genes, Viral*
  • Mutagens
  • Transcription, Genetic


  • DNA, Viral
  • Mutagens
  • DNA Restriction Enzymes