A two-part study of the aetiological role of rotavirus in intussusception

J Med Virol. 1982;9(1):51-5. doi: 10.1002/jmv.1890090108.


The aetiology of intussusception is ill-defined, with viruses being incriminated as one of many possible aetiological agents. A two-part study was performed by us to investigate the aetiological role of rotavirus in intussusception. Retrospective epidemiological data revealed a negative correlation between the incidence of rotaviral gastroenteritis and the incidence of intussusception. A prospective investigation employing electronmicroscopy, enzyme-linked immunosorbent assay (ELISA), and immunofluorescence studies of faeces and fluorescent antibody studies of sera demonstrated evidence of rotavirus infection in only 2 of 24 children with intussusception. No evidence was forthcoming in this study of an aetiological role of rotavirus in intussusception.

MeSH terms

  • Acute Disease
  • Child
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Fluorescent Antibody Technique
  • Gastroenteritis / epidemiology
  • Humans
  • Intussusception / epidemiology
  • Intussusception / etiology*
  • Male
  • Prospective Studies
  • Reoviridae*
  • Retrospective Studies
  • Rotavirus* / immunology
  • Virus Diseases*