Resistance to Moloney murine sarcoma virus (M-MuSV) tumor induction is associated with natural antibody production to "endogenous" Moloney leukemia virus (M-MuLV) in BALB/Mo mice

Tumori. 1981 Dec 31;67(6):511-20. doi: 10.1177/030089168106700601.

Abstract

BALB/Mo mice are characterized by early expression of "endogenized" M-MuLV and are resistant to M-MuSV tumor induction. Furthermore, compared to normal BALB/c mice, sera from BALB/Mo mice exhibit a significant reactivity which is specific for M-MuLV when tested in a 125I-labelled Staphylococcus protein A binding assay. The possible significance of this reactivity in conferring tumor resistance is explored.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibodies, Viral / immunology*
  • Cell Transformation, Neoplastic / immunology*
  • Cell Transformation, Viral
  • Immunity, Innate
  • Immunization
  • Mice
  • Mice, Inbred Strains
  • Moloney murine leukemia virus / immunology
  • Sarcoma Viruses, Murine / immunology
  • Time Factors
  • Tumor Virus Infections / immunology*
  • Virus Activation

Substances

  • Antibodies, Viral