Reversible resistance to the renal action of parathyroid hormone in human vitamin D deficiency

Clin Sci (Lond). 1982 Apr;62(4):381-7. doi: 10.1042/cs0620381.

Abstract

1. The response to exogenous parathyroid hormone (PTH) was tested in normal subjects and patients with osteomalacia due to vitamin D deficiency; 200 MRC units of bovine PTH were administered intravenously. 2. The rise in plasma adenosine 3':5'-cyclic monophosphate (cyclic AMP) and the increase in urinary excretion of cyclic AMP were reduced in the patients with vitamin D deficiency. After treatment with vitamin D the responses returned to normal. 3. It is suggested that this reversible resistance is due to the secondary hyperparathyroidism associated with vitamin D deficiency.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 25-Hydroxyvitamin D 2
  • Adolescent
  • Adult
  • Calcium / blood
  • Creatine / blood
  • Cyclic AMP / blood
  • Cyclic AMP / urine
  • Ergocalciferols / analogs & derivatives
  • Ergocalciferols / blood
  • Female
  • Humans
  • Kidney / physiopathology*
  • Male
  • Middle Aged
  • Parathyroid Hormone / pharmacology*
  • Stimulation, Chemical
  • Vitamin D Deficiency / metabolism
  • Vitamin D Deficiency / physiopathology*

Substances

  • Ergocalciferols
  • Parathyroid Hormone
  • 25-Hydroxyvitamin D 2
  • Cyclic AMP
  • Creatine
  • Calcium