Acyclovir - a review of the preclinical and early clinical data of a new antiherpes drug

Antiviral Res. 1981 Nov;1(4):203-12. doi: 10.1016/0166-3542(81)90011-5.

Abstract

A review of the literature on acyclovir (Zovirax), a new antiherpes drug, with particular activity against herpes simplex virus types I and II and also against varicella-zoster, Epstein-Barr, cytomegalo and herpes B viruses, is presented. The article deals with 'in vitro' and 'in vivo' efficacy in animals, animal toxicity, latency and resistance, the mechanism of action and early clinical experience.

Publication types

  • Clinical Trial
  • Review

MeSH terms

  • Acyclovir
  • Animals
  • Clinical Trials as Topic
  • Drug Resistance, Microbial
  • Guanine / analogs & derivatives*
  • Guanine / metabolism
  • Guanine / therapeutic use
  • Guanine / toxicity
  • Guinea Pigs
  • Herpes Simplex / drug therapy
  • Herpesviridae / drug effects
  • Herpesviridae Infections / drug therapy*
  • Herpesvirus 3, Human / drug effects
  • Herpesvirus 4, Human / drug effects
  • Humans
  • Intestinal Absorption
  • Keratitis, Dendritic / drug therapy
  • Kidney / drug effects
  • Kinetics
  • Mice
  • Phosphorylation
  • Rabbits
  • Simplexvirus / drug effects
  • Time Factors

Substances

  • Guanine
  • Acyclovir