Abstract
A review of the literature on acyclovir (Zovirax), a new antiherpes drug, with particular activity against herpes simplex virus types I and II and also against varicella-zoster, Epstein-Barr, cytomegalo and herpes B viruses, is presented. The article deals with 'in vitro' and 'in vivo' efficacy in animals, animal toxicity, latency and resistance, the mechanism of action and early clinical experience.
MeSH terms
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Acyclovir
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Animals
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Clinical Trials as Topic
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Drug Resistance, Microbial
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Guanine / analogs & derivatives*
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Guanine / metabolism
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Guanine / therapeutic use
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Guanine / toxicity
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Guinea Pigs
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Herpes Simplex / drug therapy
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Herpesviridae / drug effects
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Herpesviridae Infections / drug therapy*
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Herpesvirus 3, Human / drug effects
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Herpesvirus 4, Human / drug effects
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Humans
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Intestinal Absorption
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Keratitis, Dendritic / drug therapy
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Kidney / drug effects
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Kinetics
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Mice
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Phosphorylation
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Rabbits
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Simplexvirus / drug effects
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Time Factors