Adriamycin Inactivates Cytochrome C Oxidase by Exclusion of the Enzyme From Its Cardiolipin Essential Environment

Biochem Biophys Res Commun. 1982 Jan 15;104(1):314-20. doi: 10.1016/0006-291x(82)91976-3.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antibiotics, Antineoplastic / pharmacology
  • Calorimetry, Differential Scanning
  • Cardiolipins / physiology*
  • Cattle
  • Doxorubicin / pharmacology*
  • Electron Transport Complex IV / metabolism*
  • Kinetics
  • Mitochondria, Heart / enzymology*
  • Structure-Activity Relationship

Substances

  • Antibiotics, Antineoplastic
  • Cardiolipins
  • Doxorubicin
  • Electron Transport Complex IV