A T-cell line derived from normal human cord leukocytes by co-culturing with human leukemic T-cells

Gan. 1981 Dec;72(6):978-81.

Abstract

A unique T-cell line, MT-2, was established from normal human cord leukocytes of a male infant by co-culturing with leukemic T-cells from a female patient with adult T-cell leukemia. MT-2 cells expressed receptors for sheep erythrocytes and complement and were reactive with anti-T-cell and anti-Ia sera. They were negative for Fc receptors, surface immunoglobulin, and Epstein-Barr virus nuclear antigen. Chromosomally, the MT-2 line was male and most cells were shown to have a normal diploid karyotype. The cultured cells were tumorigenic when transplanted into immunosuppressed newborn hamsters.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antigens, Viral / analysis
  • Cell Line*
  • Cells, Cultured
  • Cricetinae
  • Female
  • Fetal Blood*
  • Herpesvirus 4, Human / immunology
  • Humans
  • Infant
  • Karyotyping
  • Leukemia
  • Male
  • Middle Aged
  • Neoplasms, Experimental / etiology
  • Receptors, Antigen, B-Cell / analysis
  • Receptors, Complement / analysis
  • Receptors, Fc / analysis
  • T-Lymphocytes*

Substances

  • Antigens, Viral
  • Receptors, Antigen, B-Cell
  • Receptors, Complement
  • Receptors, Fc