Effect of Prostaglandins on Elicitation of Anti-Viral-Cytolytic Activity

Immunol Lett. 1982 Mar;4(3):171-4. doi: 10.1016/0165-2478(82)90031-1.


We have studied the modulating effect of prostaglandins (PG) on the elicitation of secondary anti-vesicular stomatitis virus (VSV) cytotoxic T-lymphocytes (CTL) with viral antigens. The results indicate that PGE1 and PGE2 both inhibit the induction of anti-VSV CTLs by ultraviolet-inactivated VSV. Consistent with the result was the augmentation of anti-VSV CTL activity when VSV-primed spleen cells were cultured in the presence of indomethacin. These results suggest that PGs may modulate anti-viral CTL responses.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alprostadil
  • Animals
  • Cells, Cultured
  • Cytotoxicity, Immunologic / drug effects*
  • Dinoprostone
  • Female
  • Indomethacin / pharmacology
  • Male
  • Mice
  • Mice, Inbred BALB C
  • Prostaglandins / pharmacology*
  • Prostaglandins E / pharmacology
  • Spleen / cytology
  • T-Lymphocytes / immunology*
  • Vesicular stomatitis Indiana virus / immunology*


  • Prostaglandins
  • Prostaglandins E
  • Alprostadil
  • Dinoprostone
  • Indomethacin