Transferable Drug Resistance in Pseudomonas Patients With Premature Rupture of Membranes in Ile-Ife, Nigeria

Afr J Med Med Sci. Mar-Jun 1980;9(1-2):49-51.


Pseudomonas aeruginosa was cultured in eight patients with premature rupture of membranes in a Maternity Unit of the University of Ife Teaching Hospital Complex within a period of 48 h. Three of the strains were found to harbour R-factor DNA conferring high-level resistance to benzylpenicillin, streptomycin, chloramphenicol and tetracycline, while two strains are able to transfer this drug resistance en bloc to drug-sensitive Escherichia coli. The significance of this in the light of a continuing study of drug resistant bacteria in Ile-Ife is discussed.

MeSH terms

  • Chloramphenicol / therapeutic use
  • Drug Resistance, Microbial
  • Escherichia coli / genetics
  • Female
  • Fetal Membranes, Premature Rupture / microbiology*
  • Humans
  • Pregnancy
  • Pseudomonas Infections / drug therapy
  • Pseudomonas aeruginosa / genetics*
  • Streptomycin / therapeutic use
  • Tetracycline / therapeutic use
  • Transformation, Bacterial*


  • Chloramphenicol
  • Tetracycline
  • Streptomycin