Bioactive enteroglucagon (oxyntomodulin): present knowledge on its chemical structure and its biological activities

Peptides. 1981;2 Suppl 2:41-4. doi: 10.1016/0196-9781(81)90008-5.

Abstract

A bioactive form of enteroglucagon has been isolated from porcine jejuno-ileum according to its glucagon-like effect in liver. Enzymatic digestion followed by HPLC, dansylation and partial sequence analysis strongly suggests that this peptide contains the glucagon molecule (1--29) elongated at the C-terminal end by the octapeptide Lys-Arg-Asn-Lys-Asn-Ile-Ala-COOH and possibly modified in the N-terminal region. A specific action of bioactive enteroglucagon, increase in cAMP, has been found in the acid-secreting fundic part of the rat stomach. The term "oxyntomodulin" is therefore proposed to describe this peptide.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Cyclic AMP / metabolism
  • Gastric Fundus / drug effects
  • Gastric Fundus / metabolism
  • Gastrointestinal Hormones / pharmacology*
  • Glucagon
  • Glucagon-Like Peptides / isolation & purification
  • Glucagon-Like Peptides / pharmacology*
  • Ileum / analysis*
  • Jejunum / analysis*
  • Oxyntomodulin
  • Peptide Fragments / isolation & purification
  • Rats
  • Swine

Substances

  • Gastrointestinal Hormones
  • Oxyntomodulin
  • Peptide Fragments
  • Glucagon-Like Peptides
  • Glucagon
  • Cyclic AMP