Chemotactic requirements of bovine leukocytes

Am J Vet Res. 1982 May;43(5):757-9.

Abstract

A system was described for studying bovine leukotaxis. Chemotaxis was readily observed toward bovine serum activated by zymosan of agarose. However, bacterial culture filtrates and peptides, which were potent chemotaxins for leukocytes from other species, failed to affect bovine leukotaxis. Using conditions suitable for studying binding to leukocytes from other species, specific binding of a radiolabeled chemotactic peptide to bovine leukocytes was not apparent. These data indicate that bovine leukocytes have chemotactic requirements distinct from those of other species.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Cattle / physiology*
  • Chemotactic Factors / metabolism
  • Chemotactic Factors / pharmacology
  • Chemotaxis, Leukocyte* / drug effects
  • Dipeptides / pharmacology
  • Escherichia coli
  • Humans
  • Neutrophils / drug effects
  • Neutrophils / metabolism
  • Pepstatins / pharmacology
  • Receptors, Cell Surface / metabolism
  • Receptors, Formyl Peptide

Substances

  • Chemotactic Factors
  • Dipeptides
  • Pepstatins
  • Receptors, Cell Surface
  • Receptors, Formyl Peptide
  • Streptomyces pepsin inhibitor
  • N-formylmethionylphenylalanine
  • pepstatin