Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Clinical Trial
. 1982;76(3):245-50.
doi: 10.1007/BF00432554.

Action of Cannabidiol on the Anxiety and Other Effects Produced by Delta 9-THC in Normal Subjects

Clinical Trial

Action of Cannabidiol on the Anxiety and Other Effects Produced by Delta 9-THC in Normal Subjects

A W Zuardi et al. Psychopharmacology (Berl). .


The object of the experiment was to verify whether cannabidiol (CBD) reduces the anxiety provoked by delta 9-THC in normal volunteers, and whether this effect occurs by a general block of the action of delta 9-THC or by a specific anxiolytic effect. Appropriate measurements and scales were utilized and the eight volunteers received, the following treatments in a double-blind procedure: 0.5 mg/kg delta 9-THC, 1 mg/kg CBD, a mixture containing 0.5 mg/kg delta 9-THC and 1 mg/kg CBD and placebo and diazepam (10 mg) as controls. Each volunteer received the treatments in a different sequence. It was verified that CBD blocks the anxiety provoked by delta 9-THC, however this effect also extended to marihuana-like effects and to other subjective alterations induced by delta 9-THC. This antagonism does not appear to be caused by a general block of delta 9-THC effects, since no change was detected in the pulse-rate measurements. Several further effects were observed typical of CBD and of an opposite nature to those of delta 9-THC. These results suggest that the effects of CBD, as opposed to those of delta 9-THC, might be involved in the antagonism of effects between the two cannabinoids.

Similar articles

See all similar articles

Cited by 120 articles

See all "Cited by" articles


    1. Arch Gen Psychiatry. 1972 May;26(5):483-5 - PubMed
    1. Clin Pharmacol Ther. 1971 Jul-Aug;12(4):650-7 - PubMed
    1. Dan Med Bull. 1974 May;21(3):106-20 - PubMed
    1. Psychopharmacologia. 1974;38(4):329-38 - PubMed
    1. Res Commun Chem Pathol Pharmacol. 1974 Nov;9(3):453-62 - PubMed

Publication types