Cyclosporin A in renal transplantation: a prospective randomized trial

Surgery. 1982 Aug;92(2):175-82.


Cyclosporin A combined with prednisone was compared with standard immunosuppressive therapy (antilymphoblast globulin, prednisone, and azathioprine) in a prospective randomized trial of 100 mismatched, living related donor and cadaveric renal transplants. The results demonstrated cyclosporin A plus prednisone to be an effective immunosuppressive regimen for renal transplantation. The actuarial graft survival at 1 year was 93% for patients treated with cyclosporin A and 81% for patients treated with conventional immunosuppression. Patient survival was 98% for the cyclosporin A group and 100% for the conventional group. Cyclosporin A-treated patients had fewer rejection episodes and fewer infections complications including a marked decrease in the incidence of posttransplant cytomegalovirus infection. The side effects of cyclosporin A were mild, but nephrotoxicity caused by cyclosporin A was frequent and significant. Nephrotoxicity was reversible and managed by decreasing the daily cyclosporin A dose. It is concluded that the combination of cyclosporin A plus prednisone provides an excellent alternate immunosuppressive regimen for renal transplants as compared with conventional therapy. The consequences of long-term administration of cyclosporin A are at present unknown.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Antilymphocyte Serum / pharmacology
  • Azathioprine / pharmacology
  • Clinical Trials as Topic
  • Cyclosporins / adverse effects
  • Cyclosporins / pharmacology*
  • Cytomegalovirus Infections / etiology
  • Female
  • Graft Rejection / drug effects
  • Graft Survival / drug effects
  • Humans
  • Immunosuppressive Agents
  • Kidney Transplantation*
  • Male
  • Middle Aged
  • Postoperative Complications
  • Prednisone / pharmacology
  • Prospective Studies
  • Random Allocation
  • Transplantation Immunology / drug effects


  • Antilymphocyte Serum
  • Cyclosporins
  • Immunosuppressive Agents
  • Azathioprine
  • Prednisone