Localization of opiate and histamine H1-receptors in the primate sensory ganglia and spinal cord

Brain Res. 1982 Jun 10;241(2):197-206. doi: 10.1016/0006-8993(82)91056-3.

Abstract

The autoradiographic localizations of opiate and histamine H1-receptors were studied quantitatively and compared following dorsal root section in the primate spinal cord. High densities of opiate and H1-receptors were found in the superficial layers of the dorsal horn. Dorsal root section produced a 40-50% loss of both receptors types throughout layers I and II with no loss in deeper layers of the dorsal horn. "Bursts' of opiate and H1-receptor labelling was observed over a population of small diameter cells (35-45 micron or micrometer) in the primate dorsal root ganglion. These cells represented approximately 8% of the total cells present. Serial consecutive sections demonstrated a population of cells bearing both opiate and histamine H1-receptors.

MeSH terms

  • Animals
  • Autoradiography
  • Etorphine / metabolism
  • Ganglia, Spinal / metabolism*
  • Macaca mulatta
  • Pyrilamine / metabolism
  • Receptors, Histamine / metabolism*
  • Receptors, Histamine H1 / metabolism*
  • Receptors, Opioid / metabolism*
  • Spinal Cord / metabolism*
  • Tritium

Substances

  • Receptors, Histamine
  • Receptors, Histamine H1
  • Receptors, Opioid
  • Tritium
  • Etorphine
  • Pyrilamine