The nucleotide sequence of a human immunoglobulin C gamma1 gene

Nucleic Acids Res. 1982 Jul 10;10(13):4071-9. doi: 10.1093/nar/10.13.4071.

Abstract

We report the nucleotide sequence of a gene encoding the constant region of a human immunoglobulin gamma 1 heavy chain (C gamma 1). A comparison of this sequence with those of the C gamma 2 and C gamma 4 genes reveals that these three human C gamma genes share considerable homology in both coding and noncoding regions. The nucleotide sequence differences indicate that these genes diverged from one another approximately 608 million years ago. An examination of hinge exons shows that these coding regions have evolved more rapidly than any other areas of the C gamma genes in terms of both base substitution and deletion/insertion events. Coding sequence diversity also is observed in areas of CH domains which border the hinge.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Base Sequence
  • Biological Evolution
  • Cloning, Molecular
  • DNA Restriction Enzymes
  • DNA, Recombinant / analysis
  • Escherichia coli / genetics
  • Female
  • Fetus
  • Genes*
  • Humans
  • Immunoglobulin Constant Regions / genetics
  • Immunoglobulin Heavy Chains / genetics*
  • Immunoglobulin gamma-Chains / genetics*
  • Liver / analysis
  • Pregnancy

Substances

  • DNA, Recombinant
  • Immunoglobulin Constant Regions
  • Immunoglobulin Heavy Chains
  • Immunoglobulin gamma-Chains
  • DNA Restriction Enzymes

Associated data

  • GENBANK/J00228