Herpes simplex virus type-1 glycoprotein D gene: nucleotide sequence and expression in Escherichia coli

Science. 1982 Oct 22;218(4570):381-4. doi: 10.1126/science.6289440.


The protein coding region of the herpes simplex virus type-1 glycoprotein D (gD) gene was mapped, and the nucleotide sequence was determined. The predicted amino acid sequence of the gD polypeptide was found to contain a number of features in common with other virus glycoproteins. Insertion of this protein coding region into a bacterial expressor plasmid enabled synthesis in Escherichia coli of an immunoreactive gD-related polypeptide. The potential of this system for preparation of a type-common herpes simplex virus vaccine is discussed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Antigens, Viral / genetics
  • Base Sequence
  • Escherichia coli / genetics
  • Gene Expression Regulation
  • Genes
  • Genes, Viral
  • Glycoproteins / genetics*
  • Peptides / genetics
  • Protein Sorting Signals
  • Simplexvirus / genetics*
  • Viral Proteins / genetics*
  • Viral Proteins / immunology
  • Viral Vaccines


  • Antigens, Viral
  • Glycoproteins
  • Peptides
  • Protein Sorting Signals
  • Viral Proteins
  • Viral Vaccines

Associated data

  • GENBANK/J02217