67Ga scanning for assessment of disease activity and therapy decisions in pulmonary sarcoidosis in comparison to chest radiography, serum ACE and blood T-lymphocytes

Eur J Nucl Med. 1982;7(9):413-6. doi: 10.1007/BF00256821.


In 60 patients with histologically proven sarcoidosis, 67Ga scanning was evaluated in terms of sensitivity and specificity for assessing disease activity and compared with chest radiography, serum ACE and blood T-lymphocytes. While 67Ga scans had the highest sensitivity (94%), the specificity was only 68%. The sensitivity of chest radiography was 80%, of serum ACE and blood T-lymphocytes 77% and 48%, respectively. While in patients with radiographical type I, 67Ga scanning, chest radiography and serum ACE had a sensitivity of 92%-100%, in patients with radiographical type II-III, only 67Ga scans had a sensitivity exceeding 90%. A 67Ga score correlated significantly with serum ACE levels (r = 0.59, P less than 0.001). After effective steroid treatment, 67Ga uptake and serum ACE activities decreased markedly. While in 25% of cases, chest radiography failed to provide reliable information, 67Ga scanning and serum ACE activities always proved useful in evaluating the course of the disease and the patient's response to steroid therapy. A negative 67Ga scan together with normal serum ACE levels seem to have a high predictive value for excluding active sarcoidosis.

Publication types

  • Comparative Study

MeSH terms

  • Adolescent
  • Adrenal Cortex Hormones / therapeutic use
  • Adult
  • Aged
  • Female
  • Gallium Radioisotopes
  • Humans
  • Leukocyte Count*
  • Lung Diseases / diagnostic imaging*
  • Lung Diseases / drug therapy
  • Male
  • Middle Aged
  • Peptidyl-Dipeptidase A / blood*
  • Radiography
  • Radionuclide Imaging
  • Sarcoidosis / diagnostic imaging*
  • Sarcoidosis / drug therapy
  • T-Lymphocytes*


  • Adrenal Cortex Hormones
  • Gallium Radioisotopes
  • Peptidyl-Dipeptidase A