Mechanism of activation of a human oncogene

Nature. 1982 Nov 11;300(5888):143-9. doi: 10.1038/300143a0.

Abstract

The oncogene of the human EJ bladder carcinoma cell lines arose via alteration of a cellular proto-oncogene. Experiments are presented that localize the genetic lesion that led to activation of the oncogene. The lesion has no affect on levels of expression of the oncogene. Instead, it affects the structure of the oncogene-encoded protein.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Cell Line
  • Cell Transformation, Neoplastic
  • Cloning, Molecular
  • DNA Restriction Enzymes / metabolism
  • Gene Expression Regulation
  • Humans
  • Molecular Weight
  • Mutation*
  • Neoplasm Proteins / biosynthesis
  • Oncogenes*
  • RNA, Neoplasm / analysis
  • Transfection
  • Urinary Bladder Neoplasms / genetics*

Substances

  • Neoplasm Proteins
  • RNA, Neoplasm
  • DNA Restriction Enzymes

Associated data

  • GENBANK/J00206
  • GENBANK/J00276
  • GENBANK/J00277
  • GENBANK/K00954