The effect of high-sodium and low-sodium intakes on blood pressure and other related variables in human subjects with idiopathic hypertension

Am J Med. 1978 Feb;64(2):193-8. doi: 10.1016/0002-9343(78)90045-1.


Nineteen patients with hypertension in whom all known causes of blood pressure elevation had been ruled out were classified as "salt-sensitive" or "nonsalt-sensitive" from the changes in blood pressure with changes in sodium intake from 9 meq to 249 meq/day. With the diet containing 249 meq sodium per day, there were no statistically significant differences in plasma sodium, potassium, chloride, aldosterone, cortisol or renin activity, or in urinary potassium, aldosterone or 17-hydroxycorticosteroids between the two groups. The "salt-sensitive" patients retained more sodium on the high-sodium diet than did the patients who were not sensitive to salt ("nonsalt-sensitive"); accordingly, sodium induced more weight gain in the salt-sensitive patients.

MeSH terms

  • Adult
  • Aldosterone / blood
  • Blood Pressure / drug effects*
  • Blood Volume / drug effects
  • Body Weight
  • Diet
  • Humans
  • Hypertension* / classification
  • Hypertension* / metabolism
  • Middle Aged
  • Renin / blood
  • Sodium / metabolism
  • Sodium Chloride / pharmacology*


  • Sodium Chloride
  • Aldosterone
  • Sodium
  • Renin