Intrinsic actions of benzodiazepine antagonists

Neurosci Lett. 1982 Oct 8;32(2):165-8. doi: 10.1016/0304-3940(82)90268-3.

Abstract

RO 15-1788 (4-20 mg/kg), both alone and in combination with chlordiazepoxide (5 mg/kg), increased exploratory head-dipping in an holeboard above control levels. This intrinsic action of a benzodiazepine antagonist is not reversed, and is even augmented, by chlordiazepoxide. RO 15-1788 alone had no effect on locomotor activity, but antagonized the sedative effects of chlordiazepoxide. beta-CCE (1 and 2 mg/kg) was without effect on locomotor activity, but the higher dose reduced head-dipping.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Benzodiazepinones / pharmacology*
  • Brain / drug effects
  • Carbolines / pharmacology*
  • Chlordiazepoxide / pharmacology*
  • Dose-Response Relationship, Drug
  • Exploratory Behavior / drug effects*
  • Flumazenil
  • Indoles / pharmacology*
  • Male
  • Motor Activity / drug effects*
  • Muridae
  • Receptors, Drug / drug effects*
  • Receptors, GABA-A

Substances

  • Benzodiazepinones
  • Carbolines
  • Indoles
  • Receptors, Drug
  • Receptors, GABA-A
  • Flumazenil
  • Chlordiazepoxide
  • beta-carboline-3-carboxylic acid ethyl ester