Abstract
RO 15-1788 (4-20 mg/kg), both alone and in combination with chlordiazepoxide (5 mg/kg), increased exploratory head-dipping in an holeboard above control levels. This intrinsic action of a benzodiazepine antagonist is not reversed, and is even augmented, by chlordiazepoxide. RO 15-1788 alone had no effect on locomotor activity, but antagonized the sedative effects of chlordiazepoxide. beta-CCE (1 and 2 mg/kg) was without effect on locomotor activity, but the higher dose reduced head-dipping.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Benzodiazepinones / pharmacology*
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Brain / drug effects
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Carbolines / pharmacology*
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Chlordiazepoxide / pharmacology*
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Dose-Response Relationship, Drug
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Exploratory Behavior / drug effects*
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Flumazenil
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Indoles / pharmacology*
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Male
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Motor Activity / drug effects*
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Muridae
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Receptors, Drug / drug effects*
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Receptors, GABA-A
Substances
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Benzodiazepinones
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Carbolines
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Indoles
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Receptors, Drug
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Receptors, GABA-A
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Flumazenil
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Chlordiazepoxide
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beta-carboline-3-carboxylic acid ethyl ester