Comparison of the inhibitory action of delta-9-tetrahydrocannabinol and petroleum spirit extract of herbal cannabis on human sperm motility

C Y Hong; D M Chaput de Saintonge; P Turner; J W Fairbairn

doi:10.1177/096032718200100207

Comparison of the inhibitory action of delta-9-tetrahydrocannabinol and petroleum spirit extract of herbal cannabis on human sperm motility

Hum Toxicol. 1982 Mar;1(2):151-4. doi: 10.1177/096032718200100207.

Authors

C Y Hong, D M Chaput de Saintonge, P Turner, J W Fairbairn

PMID: 6293959
DOI: 10.1177/096032718200100207

Abstract

1 Using the trans-membrane migration method to measure drug effects on human sperm motility, it is found that delta-9-tetrahydrocannabinol is the major constituent of cannabis which inhibits sperm motility and unlike the cataleptic effect, other constituents in the petroleum spirit extract do not potentiate this effect significantly. 2 It is suggested that the mechanisms for sperm immobilization and cataleptic effects are different.

Publication types

Comparative Study
Research Support, Non-U.S. Gov't

MeSH terms

Cannabis*
Dronabinol / pharmacology*
Humans
In Vitro Techniques
Male
Plant Extracts / pharmacology*
Sperm Motility / drug effects*

Substances

Plant Extracts
Dronabinol