The roles of individual polyoma virus early proteins in oncogenic transformation

Nature. 1982 Dec 23;300(5894):713-8. doi: 10.1038/300713a0.

Abstract

The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.

MeSH terms

  • Animals
  • Antigens, Viral / genetics*
  • Antigens, Viral, Tumor
  • Cell Transformation, Neoplastic*
  • Cell Transformation, Viral*
  • Cells, Cultured
  • Culture Media
  • DNA, Viral / genetics
  • Oncogenes
  • Polyomavirus / genetics
  • Polyomavirus / immunology
  • Rats
  • Viral Proteins / physiology*

Substances

  • Antigens, Viral
  • Antigens, Viral, Tumor
  • Culture Media
  • DNA, Viral
  • Viral Proteins