A tandem repeat gene in a picornavirus

Nucleic Acids Res. 1982 Oct 25;10(20):6441-50. doi: 10.1093/nar/10.20.6441.

Abstract

Three closely related genes for the small genome-linked protein (VPg) of picornaviruses have been identified by sequence analysis as a tandem repeat in the genome of Foot and Mouth Disease Virus (FMDV), strain O1K. This unusual structure was also found in the genome of strain C1O, belonging to a different FMDV serotype. Predicted biochemical properties of the three VPg gene products are in excellent agreement with the data from protein analysis of a heterogeneous VPg population from a third FMDV serotype, strain A10 (1). Taken together, these data indicate that the VPgs from all three genes function equally well in vivo. This is the first report of a tandem repeat gene in a viral genome.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amino Acid Sequence
  • Aphthovirus / genetics*
  • DNA
  • DNA Restriction Enzymes
  • Genes, Viral*
  • Plasmids
  • Protein Biosynthesis
  • Repetitive Sequences, Nucleic Acid
  • Species Specificity
  • Transcription, Genetic

Substances

  • DNA
  • DNA Restriction Enzymes

Associated data

  • GENBANK/J02190
  • GENBANK/J02191