Alteration of benzo(a)pyrene metabolism by acute ethanol or corticosterone

Res Commun Chem Pathol Pharmacol. 1982 Sep;37(3):375-84.


The effect of acute ethanol (3 g/kg and 5 g/kg) or corticosterone (12.5 mg/kg) on benzo(a)pyrene metabolism was measured in microsomes from 3-methylcholanthrene pretreated rats. BAP disappearance was inhibited 34% at 5 g/kg but unaltered at 3 g/kg ethanol. Corticosterone administration inhibited BAP metabolism 53%. In adrenalectomized (ADX) rats, alcohol or CS did not decrease BAP metabolism (compared to untreated ADX rats). However, corticosterone in vitro inhibited BAP metabolism in a dose-related fashion in washed microsomes from untreated rats. These results demonstrate that acute ethanol and corticosterone administration alter benzo(a)pyrene metabolism. Furthermore, the inhibition requires an intact adrenal.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adrenalectomy
  • Animals
  • Benzo(a)pyrene
  • Benzopyrenes / metabolism*
  • Corticosterone / pharmacology*
  • Ethanol / pharmacology*
  • Male
  • Rats
  • Rats, Inbred Strains


  • Benzopyrenes
  • Benzo(a)pyrene
  • Ethanol
  • Corticosterone