Long-term follow-up and bronchial reactivity testing in survivors of the adult respiratory distress syndrome

Am Rev Respir Dis. 1978 Mar;117(3):449-54. doi: 10.1164/arrd.1978.117.3.449.


Long-term follow-up of 9 survivors of the adult respiratory distress syndrome at 39 to 83 months demonstrated 2 patients with continued improvement of their restrictive pattern, 3 patients with stable mild obstructive disease, one patient who had had chronic obstructive pulmonary disease before the adult respiratory distress syndrome with continued pulmonary deterioration, and 4 patients without symptoms and with normal pulmonary function tests. Attention is drawn to bronchial reactivity as defined by a bronchodilator response of more than 60 per cent increase in maximal mid-expiratory flow, positive methacholine challenge, or development of bronchospasm after exercise in 3 patients having clinical symptoms of wheezing on recovery.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Female
  • Follow-Up Studies
  • Forced Expiratory Volume
  • Humans
  • Lung / drug effects
  • Lung / physiopathology*
  • Male
  • Maximal Midexpiratory Flow Rate
  • Methacholine Compounds / pharmacology
  • Middle Aged
  • Respiratory Distress Syndrome / physiopathology*
  • Vital Capacity


  • Methacholine Compounds