Activity of ketoconazole and its deacyl derivative against Plasmodium falciparum and Candida isolates

Antimicrob Agents Chemother. 1982 Nov;22(5):917-9. doi: 10.1128/AAC.22.5.917.

Abstract

Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole, based on [(3)H]hypoxanthine uptake and quantitative parasite counts. In contrast, there were no significant differences between these drugs in their activity against clinical isolates of Candida spp.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Antifungal Agents / pharmacology*
  • Candida / drug effects*
  • Imidazoles / pharmacology*
  • Ketoconazole
  • Piperazines / pharmacology*
  • Plasmodium falciparum / drug effects*

Substances

  • Antifungal Agents
  • Imidazoles
  • Piperazines
  • deacylketoconazole
  • Ketoconazole