Abstract
Deacylketoconazole was 15- to 50-fold more active against Plasmodium falciparum than was ketoconazole, based on [(3)H]hypoxanthine uptake and quantitative parasite counts. In contrast, there were no significant differences between these drugs in their activity against clinical isolates of Candida spp.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Antifungal Agents / pharmacology*
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Candida / drug effects*
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Imidazoles / pharmacology*
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Ketoconazole
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Piperazines / pharmacology*
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Plasmodium falciparum / drug effects*
Substances
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Antifungal Agents
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Imidazoles
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Piperazines
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deacylketoconazole
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Ketoconazole