Prostaglandins and human lung carcinomas

Br J Cancer. 1982 Dec;46(6):888-93. doi: 10.1038/bjc.1982.298.


Lung primary carcinomas and normal tissue from 136 patients have been extracted for prostaglandins, and the findings examined in relation to histology. In most cases, tumours yielded more prostaglandin-like material (PG-lm), as judged by bioassay, than did normal tissue from the same lungs. Amounts varied with tumour types, in the following ascending order: small-cell carcinomas, large-cell undifferentiated carcinomas, well-differentiated squamous carcinomas, poorly-differentiated adenocarcinomas, poorly differentiated squamous carcinomas, and well-differentiated adenocarcinomas. Tumour PG-lm was highest when necrosis or the neutrophil content of the tumours were moderate, whereas PG-lm from normal lung tissue correlated with the number of macrophages. Chromatography indicated the presence of various prostaglandins, in agreement with our recent findings using gas chromatography--mass spectrometry.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / metabolism
  • Biological Assay
  • Carcinoma, Small Cell / metabolism
  • Carcinoma, Squamous Cell / metabolism
  • Dinoprostone
  • Humans
  • Lung / metabolism
  • Lung Neoplasms / metabolism*
  • Mitosis
  • Prostaglandins / metabolism*
  • Prostaglandins E / metabolism


  • Prostaglandins
  • Prostaglandins E
  • Dinoprostone