Intraocular irrigating solutions. A comparative study of BSS Plus and lactated Ringer's solution

Arch Ophthalmol. 1978 Mar;96(3):516-20. doi: 10.1001/archopht.1978.03910050284021.


Isolated human corneas maintained normal corneal thickness and endothelial ultrastructural integrity throughout a three-to four-hour period of perfusion of BSS plus to the endothelial surface. By comparison, only one of six human corneas perfused with lactated Ringer's solution was able to maintain normal thickness and ultrastructural integrity. The other five corneas perfused with lactated Ringer's solution showed various degrees of endothelial cell breakdown and corneal swelling during three hours of perfusion. The results of these studies suggest that BSS plus is a better solution for maintenance of human corneal endothelium during long-term (one- to three-hour) surgical procedures.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Cornea / drug effects*
  • Cornea / ultrastructure
  • Drug Combinations
  • Drug Evaluation
  • Glutathione / administration & dosage
  • Glutathione / pharmacology*
  • Humans
  • Lactates / administration & dosage
  • Lactates / pharmacology
  • Microscopy, Electron, Scanning
  • Ophthalmic Solutions / administration & dosage
  • Ophthalmic Solutions / pharmacology*
  • Perfusion
  • Saline Solution, Hypertonic / pharmacology*
  • Sodium Chloride / pharmacology*
  • Time Factors


  • Drug Combinations
  • Lactates
  • Ophthalmic Solutions
  • Saline Solution, Hypertonic
  • Sodium Chloride
  • Glutathione