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. 1982 Dec;22(6):1026-30.
doi: 10.1128/AAC.22.6.1026.

Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds

K O Smith, K S Galloway, K K Ogilvie, U O Cheriyan

Synergism among BIOLF-62, phosphonoformate, and other antiherpetic compounds

K O Smith et al. Antimicrob Agents Chemother. 1982 Dec.

Abstract

9-[[2-Hydroxy-1-(hydroxymethyl)ethoxy]methyl]guanine (BIOLF-62) is highly synergistic with either phosphonoformate or phosphonoacetate when used in combination against herpes simplex virus types 1 and 2 in vitro. Acycloguanosine did not show significant synergism with these two compounds. Bromovinyldeoxyuridine and phosphonoformate were highly synergistic against herpes simplex virus type 2, but not against type 1.

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