Nucleotide sequence of the retroviral leukemia gene v-myb and its cellular progenitor c-myb: the architecture of a transduced oncogene

Cell. 1982 Dec;31(2 Pt 1):453-63. doi: 10.1016/0092-8674(82)90138-6.


The oncogene (v-myb) of avian myeloblastosis virus and a large portion of its cellular homolog (c-myb) have been molecularly cloned and sequenced. The portion of c-myb we analyzed contains seven interspersed segments (or exons). Fusion of these exons creates a continuous nucleotide sequence that is remarkably similar to the sequence of v-myb and that potentially encodes a protein very similar to that specified by v-myb. Comparisons between the sequences of v-myb and c-myb indicate that transduction of c-myb to form v-myb probably resulted from an initial DNA rearrangement and the subsequent use of a spliced RNA as an intermediate.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Animals
  • Avian Leukosis Virus / genetics*
  • Avian Myeloblastosis Virus / genetics*
  • Bacteriophage lambda / genetics
  • Base Sequence
  • Chickens
  • Cloning, Molecular*
  • DNA Restriction Enzymes
  • Genes, Viral*
  • Oncogenes*
  • Transduction, Genetic*


  • DNA Restriction Enzymes

Associated data

  • GENBANK/J02011
  • GENBANK/J02012
  • GENBANK/L00052
  • GENBANK/L00053
  • GENBANK/L00054
  • GENBANK/L00055
  • GENBANK/L00056