Polymorphism of the Hinf I restriction site located 1 Kb 5' to the human beta-globin gene

Hum Genet. 1982;62(2):121-3. doi: 10.1007/BF00282298.

Abstract

Mapping of the DNA from 14 Mediterranean subjects indicates a genetic variation in an Hinf I recognition site located 1 kilobase 5' to the beta-globin gene. This Hinf I site was found associated with eight beta-thalassemic genes and 11 normal beta genes, and hence is not specifically linked to beta-thalassemia.

MeSH terms

  • Base Sequence
  • Chromosome Mapping*
  • DNA Restriction Enzymes / genetics*
  • Genes, Regulator
  • Globins / genetics*
  • Humans
  • Polymorphism, Genetic*
  • Thalassemia / genetics

Substances

  • Globins
  • DNA Restriction Enzymes