Further studies on the effect of adenosine cyclic monophosphate derivatives on cell proliferation in the jejunal crypts of rat

Clin Exp Pharmacol Physiol. 1982 Nov-Dec;9(6):671-4. doi: 10.1111/j.1440-1681.1982.tb00839.x.

Abstract

1. Cell proliferation in the jejunal crypt epithelium of rat was measured using a stathmokinetic technique. 2. Sodium butyrate was found to promote jejunal crypt cell proliferation. 3. N6, O2'-Dibutyryl cyclic adenosine monophosphate (cAMP), N6-monobutyryl-cAMP and N6-monobutyryl-8-bromo-cAMP were found to inhibit cell proliferation when compared to sodium butyrate treated tissues. 4. 8-Chlorophenylthio-cAMP was found to inhibit cell division when compared to untreated animals. 5. O2'-Monobutyryl cAMP and 8-bromo-cAMP were not found to inhibit cell proliferation.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Bucladesine / pharmacology
  • Cell Division / drug effects
  • Cyclic AMP / analogs & derivatives*
  • Cyclic AMP / pharmacology
  • Intestinal Mucosa / drug effects*
  • Jejunum / drug effects*
  • Male
  • Mitosis / drug effects
  • Rats
  • Rats, Inbred Strains
  • Vinblastine / pharmacology

Substances

  • Vinblastine
  • Bucladesine
  • Cyclic AMP