In-vitro monitoring of cell-mediated immunity to dinitrochlorobenzene

Lancet. 1976 Nov 27;2(7996):1170-1. doi: 10.1016/s0140-6736(76)91683-4.

Abstract

A dinitrochlorobenzene (D.N.C.B.)/red-blood-cell conjugate inhibited migration of leucocytes which came from D.N.C.B. sensitised patients. This effect provided the basis for a rapid, sensitive, and quantitative in-vitro measure of D.N.C.B. sensitivity. Frequent serial measurement of cell-mediated immunity was possible with the test, provided D.N.C.B. sensitivity was maintained by occasional skin patch tests.

MeSH terms

  • Cell Migration Inhibition
  • Dinitrochlorobenzene / immunology*
  • Dinitrochlorobenzene / pharmacology
  • Humans
  • Hypersensitivity, Delayed / diagnosis
  • Immunity, Cellular*
  • In Vitro Techniques
  • Leukocytes / immunology
  • Nitrobenzenes / immunology*
  • Patch Tests
  • Time Factors

Substances

  • Dinitrochlorobenzene
  • Nitrobenzenes