Kinetic study of smoking marijuana

J Pharmacokinet Biopharm. 1982 Oct;10(5):495-506. doi: 10.1007/BF01059033.


Six subjects each smoked a 1% marijuana cigarette and 2 hr later smoked a second one. Plasma levels of delta-9-tetrahydrocannabinol were measured for 9 hr with a radioimmunoassay. Heart rate and self-reported "high" were measured for 2 hr after each cigarette. All three measures showed a rapid increase after the start of smoking with Cmax occurring before the end of smoking. There was a strong correlation between decrease in heart rate and plasma levels from 10 min after smoking until 120 min. All pharmacodynamic response measures returned to baseline values within approximately 2 hr.

MeSH terms

  • Adult
  • Dronabinol / blood*
  • Dronabinol / pharmacology
  • Female
  • Heart Rate / drug effects
  • Humans
  • Male
  • Radioimmunoassay


  • Dronabinol