Multiple-drop study of topically applied 1% delta 9-tetrahydrocannabinol in human eyes

Arch Ophthalmol. 1983 Apr;101(4):591-3. doi: 10.1001/archopht.1983.01040010591012.


Twenty-eight male volunteers were given either 1% delta 9-tetrahydrocannabinol (delta 9-THC) or vehicle alone (light mineral oil). They used the medication four times per day for one week. Five volunteers, four of which used vehicle alone, discontinued the study because of burning sensation and lid swelling. In the 23 volunteers who completed the study, there was no difference in intraocular pressure between eyes treated with 1% delta 9-THC and controls.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Administration, Topical
  • Blood Pressure / drug effects
  • Clinical Trials as Topic
  • Double-Blind Method
  • Dronabinol / pharmacology*
  • Eye / drug effects*
  • Humans
  • Intraocular Pressure / drug effects
  • Male
  • Ophthalmic Solutions
  • Respiration / drug effects


  • Ophthalmic Solutions
  • Dronabinol